millipore,密理博,HLINJMAG-75K,MILLIPLEX MAP Human Liver Injury Magnetic Bead Panel - Toxicity Multiplex Assay
重要规格表
| Analytes Available | Species Reactivity | Key Applications | Detection Methods |
|---|---|---|---|
| ARG1, GSTα, SDH, 5'-NT/CD73, Malate dehydrogenase 1 (MDH1) | H | Mplex | Luminex xMAP |
| Description | |
|---|---|
| Catalogue Number | HLINJMAG-75K |
| Trade Name |
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| Description | MILLIPLEX MAP Human Liver Injury Magnetic Bead Panel - Toxicity Multiplex Assay |
| Overview | The MILLIPLEX® MAP Human Liver Injury Panel contains all the components necessary to simultaneous quantify the following 5 analytes in serum and plasma samples: • Liver-Type Arginase 1 (ARG1)* • Malate dehydrogenase 1 (MDH1)* • α-glutathione S-transferase (GSTα)* • Sorbitol Dehydrogenase (SDH)* • 5'-Nucleotidase/CD73 (5’-NT) *ARG1, GSTα, and SDH are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing. MILLIPLEX® MAP offers the broadest selection of analytes across a wide range of disease states and species. Once the analytes of interest have been identified, you can rely on the quality that we build into each kit to produce results you can trust. In addition to the assay characteristics listed in the protocol, other performance criteria evaluated during the validation process include: cross-reactivity, dilution linearity, kit stability, and sample behavior (e.g. detectability and stability). |
| Background Information | Drug toxicity is the leading cause of acute liver failure in the United States. Patients with liver damage generally display elevated amounts of specific liver proteins in serum; these proteins can serve as biomarkers of drug-related liver toxicity. Monitoring these biomarkers can greatly help clinicians avoid drug-induced liver failure. Performing laboratory tests to characterize the side effects of potential therapeutics is an essential part of drug development. The search for sensitive, organ-specific toxicity biomarkers is complemented by the development of novel assays to measure these critical analytes. Liver-Type Arginase 1 (ARG1), α-glutathione Stransferase (GSTα), Malate dehydrogenase 1 (MDH1) and Sorbitol Dehydrogenase (SDH) are biomarkers listed in the Predictive Safety Testing Consortium (PSTC) project pipeline which have a strong translational role in drug safety testing. 5'-Nucleotidase/CD73 (5’-NT) is a traditional biomarker recognized by both the Food and Drug Administration (FDA) and its European counterpart, the European Medicines Agency (EMA). |
| Product Information | |
|---|---|
| Detection method | Luminex xMAP |
| Configuration | Design your multiplex kit by choosing available analytes within this panel. |
| Precision, % |
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| Panel Type | MAGNETIC Toxicity |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | The analytes available for this multiplex kit are: Liver-type arginase 1 (ARG1), α-glutathianone S-transferase (GSTα), malate dehydrogenase 1 (MDH1), sorbitol dehydrogenase (SDH), and 5'-Nucleotidase (5'-NT/CD73). |
| Key Applications |
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| Application Notes | • This is a same day assay. • This assay uses 25uL of diluted (1:5) serum or plasma samples. Tissue culture supernatants may require dilution, as well. A two hour or overnight incubation can be used. |
| Biological Information | |
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| Specificity | There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel. |
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| Analytes Available |
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| Assay Panel | Everything you need in a single kit. |
| Cross Reactivity | There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel. |
| Accuracy |
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| Physicochemical Information | |
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| Sensitivity |
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| Linearity of Dilution | Contact technical support for this information. |
| Standard Curve Range |
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| Product Usage Statements | |
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| Usage Statement |
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| Storage and Shipping Information | |
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| Storage Conditions | Recommended storage for kit components is 2 - 8°C. |
| Packaging Information | |
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| Material Size | 96-well plate |
