millipore,
密理博,HCABMAG-13K,MILLIPLEX MAP Human Cancer Autoantibody Magnetic Bead Panel - Cancer Multiplex Assay
重要规格表
| Analytes Available | Species Reactivity | Key Applications | Detection Methods |
|---|
| CCNB1/Cyclin B1, CTAG1B/NY-ESO-1, ENO1, Galectin-1 (GAL1), Galectin-3, ErbB2/HER2, HIF-1α, HSP60, IGF2BP2/IMP2, IGF2BP3/IMP3, Mucin-1 (MUC1), P16-INK4a, p53, Sox2, Survivin/BIRC5
| H
| Mplex
| Luminex xMAP
|
| Description
|
| Catalogue Number | HCABMAG-13K |
| Trade Name |
|
| Description | MILLIPLEX® MAP Human Cancer Autoantibody Magnetic Bead Panel - Cancer Multiplex Assay |
| Overview | The MILLIPLEX® MAP Human Cancer Autoantibody Magnetic Bead Panel is a 15-plex kit to be used for the simultaneous quantification of autoantibodies to any or all of the following analytes in serum and plasma samples: Alpha-enolase (ENO1), Cancer/Testis Antigen 1B (CTAG1B/NY-ESO-1), Cyclin-dependent kinase 4 inhibitor A (p16-INK4a), G2/mitotic-specific cyclin-B1 (CCNB1), Galactose-specific lectin-1 (Galectin 1), Galactose-specific lectin-3 (Galectin 3), Heat shock protein 60 (HSP60), Hypoxia-inducible factor 1-alpha (HIF1α), Insulin-like growth factor 2 mRNA-binding protein 2 (IMP-2), Insulin-like growth factor 2 mRNA-binding protein 3 (IMP-3), Mucin 1 (MUC1), Receptor tyrosine-protein kinase (HER2/ErbB2), sex determining region Y (SRY)-box 2 (SOX2), Survivin (Survivin/BIRC5), and Tumor protein p53 (p53). For this particular panel, four assay control beads are included as part of the base kit format. |
| Background Information | Cancer autoantibodies have been studied as reporters of early carcinogenesis and indicators of cancer prognosis. Autoantibodies to tumor-associated antigens are putative cancer biomarkers, as these autoantibodies are abundant, detectable in early stages, and stable in serum. These autoantibodies may be developed from humoral immune responses to the changes in the expression levels of tumor-associated self-antigens, misfolded proteins, mutant antigens, and proteins involved in inflammation and the cellular death process. While the frequency of cancer autoantibody responses to an individual tumor antigen is typically low, the response to a multiplexed panel of antigens could be much higher. An optimized multiplex autoantibody panel to common tumor-associated antigens can improve the potential of using autoantibodies as biomarkers to study cancer development and progression, and it can serve as a simple and affordable tool in evaluating large numbers of patient samples for multiple cancer types. |
| Product Information
|
| Detection method | Luminex xMAP |
| Configuration | Design your multiplex kit by choosing available analytes within this panel. |
| Precision, % |
- Intra-assay <10%
- Inter-assay <20%
|
| Panel Type | MAGNETIC Circulating Cancer |
| Applications
|
| Application | The Human Cancer Autoantibody Panel, using the Luminex xMAP technology, enables the simultaneous analysis of 15 cancer autoantibodies in human serum and plasma samples. |
| Key Applications |
|
| Application Notes | • This is assay yields results in Median Fluorescence Intensity (MFI).
• Four assay control beads are included in the base kit.
• This is an overnight assay.
• This assay requires 25 µL of 1:100 diluted plasma or serum. |
| Biological Information
|
| Species Reactivity |
|
| Analytes Available |
- CCNB1/Cyclin B1
- CTAG1B/NY-ESO-1
- ENO1
- Galectin-1 (GAL1)
- Galectin-3
- ErbB2/HER2
- HIF-1α
- HSP60
- IGF2BP2/IMP2
- IGF2BP3/IMP3
- Mucin-1 (MUC1)
- P16-INK4a
- p53
- Sox2
- Survivin/BIRC5
|
| Assay Panel | Everything you need in a single kit. |
| Product Usage Statements
|
| Usage Statement |
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
|
| Storage and Shipping Information
|
| Storage Conditions | Recommended storage for kit components is 2 - 8°C. |
| Packaging Information
|
| Material Size | 96-well plate |
| Material Package | 96 well plate |
