millipore,
密理博,HAIAB-10K,MILLIPLEX MAP Human Autoimmune Autoantibody Panel
重要规格表
| Analytes Available | Species Reactivity | Key Applications | Detection Methods |
|---|
| β2-Glycoprotein, C1q, CENP-B (Centromere Protein B), CENP-A (Centromere Protein A), Jo-1, Ku, Mi-2, Myeloperoxidase (MPO), PCNA (Proliferating Cell Nuclear Antigen A), PL-12 (Alanyl-tRNA synthetase), PM/Scl 100, Proteinase 3, RNP (Ribonucleoprotein), RNP/Smith (RNP/Sm), Ribosomal P, Scl-70, Sm, SSB/La (Sjögren’s Syndrome-related antigen B/La), SSA/Ro60 (Sjögren’s Syndrome-related antigen A/Ro60 kDa), SSA/Ro52 (Sjögren’s Syndrome-related antigen A/Ro52 kDa)
| H
| Mplex
| Luminex xMAP
|
| Description
|
| Catalogue Number | HAIAB-10K |
| Trade Name |
|
| Description | MILLIPLEX MAP Human Autoimmune Autoantibody Panel |
| Overview | The MILLIPLEX® MAP Human Autoimmune Autoantibody Magnetic Bead Panel is a 20-plex kit to be used for the simultaneous detection and profiling of any or all of the following analytes in serum and plasma samples: Anti-C1q, Anti-Centromere Protein A (CENP-A), Anti-Centromere Protein B (CENP-B), Anti-β 2-Glycoprotein, Anti-Jo-1, Anti-Ku, Anti-Mi-2, Anti-Myeloperoxidase, Anti-Proliferating cell nuclear antigen A (PCNA), Anti-Alanyl-tRNA synthetase (PL-12), Anti-PM/Scl-100, Anti-Proteinase 3, Anti-Ribosomal P, Anti-Ribonucleoprotein (RNP), Anti-RNP/Smith (RNP/Sm), Anti-Scl-70, Anti-Sm, Anti-Sjögren’s Syndrome-related antigen B/La (SSB/La), Anti-Anti-Sjögren’s Syndrome-related antigen A/Ro52 kDa (SSA/Ro52), Anti-Sjögren’s Syndrome-related antigen A/Ro60 kDa (SSA/Ro60). For this particular panel, 4 assay control beads are also included as part of the base kit format. |
| Background Information | Autoantibody formation is principal to the pathogenesis of a variety of autoimmune diseases. Dysregulated apoptosis and the subsequent defective clearance of cellular debris leads to the exposure of autoantigens and the generation of autoantibodies. The presence of autoantibodies may indicate disease activity, prognosis, and clinical associations related to a variety of autoimmune diseases. These autoimmune diseases include, but are not limited to, Sjögren’s Syndrome, Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, Systemic Sclerosis, Calcinosis, Raynaud’s phenomenon, esophageal dysmotility, sclerodactyly, telangiectasia (CREST syndrome), Polymyositis/Dermatomyositis, Vasculitis, Anti-Phospholipid Syndrome, and various overlap syndromes of these diseases. |
| Product Information
|
| Detection method | Luminex xMAP |
| Configuration | Design your multiplex kit by choosing available analytes within this panel. |
| Precision, % |
- Intra-assay: <10%
- Inter-assay: <20%
|
| Panel Type | MAGNETIC Immune Response |
| Applications
|
| Application | The Human Autoimmune Autoantibody panel is a bead-based multiplex assay based on the Luminex xMAP technology which enables the simultaneous analysis of autoimmune autoantibodies in human serum and plasma samples. |
| Key Applications |
|
| Application Notes | • This is assay yields results in Median Fluorescence Intensity (MFI).
• Four assay control beads are included in the base kit.
• This is an overnight assay.
• This assay requires 25 µL of 1:100 diluted plasma or serum. |
| Biological Information
|
| Species Reactivity |
|
| Analytes Available |
- β2-Glycoprotein
- C1q
- CENP-B (Centromere Protein B)
- CENP-A (Centromere Protein A)
- Jo-1
- Ku
- Mi-2
- Myeloperoxidase (MPO)
- PCNA (Proliferating Cell Nuclear Antigen A)
- PL-12 (Alanyl-tRNA synthetase)
- PM/Scl 100
- Proteinase 3
- RNP (Ribonucleoprotein)
- RNP/Smith (RNP/Sm)
- Ribosomal P
- Scl-70
- Sm
- SSB/La (Sjögren’s Syndrome-related antigen B/La)
- SSA/Ro60 (Sjögren’s Syndrome-related antigen A/Ro60 kDa)
- SSA/Ro52 (Sjögren’s Syndrome-related antigen A/Ro52 kDa)
|
| Assay Panel | Everything you need in a single kit. |
| Cross Reactivity | Samples were incubated with no antigen, irrelevant antigen, or specific antigen. Incubation with a partcular antigen led to selective abrogation of the reactivity, while reactivity was unaffected by the irrelevant antigen. |
| Product Usage Statements
|
| Usage Statement |
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
|
| Storage and Shipping Information
|
| Storage Conditions | Recommended storage for kit components is 2 - 8°C. |
| Packaging Information
|
| Material Size | 96-well plate |
| Material Package | 96 well plate |
