millipore,
密理博,HNDG1MAG-36K,MILLIPLEX MAP Human Neurodegenerative Disease Magnetic Bead Panel 1 - Neuroscience Multiplex Assay
重要规格表
| Analytes Available | Species Reactivity | Key Applications | Detection Methods |
|---|
| α2-Macroglobulin, Apo Al, Apo CIII, Apo E, Complement C3, Complement Factor H
| H
| Mplex
| Luminex xMAP
|
| Description
|
| Catalogue Number | HNDG1MAG-36K |
| Trade Name |
|
| Description | MILLIPLEX MAP Human Neurodegenerative Disease Magnetic Bead Panel 1 - Neuroscience Multiplex Assay |
| Overview | The MILLIPLEX® MAP Human Neurodegenerative Magnetic Bead Panel 1 (HNDG1MAG-36K) is to be used for the simultaneous quantification of the following 7 analytes in any combination: α-2-Macroglobulin, Apo A1, Apo CIII, Apo E, Complement C3 and Complement Factor H. This kit may be used for the analysis of all above analytes in human serum, plasma, and cerebrospinal fluid samples.
References:
Acta Neuropathol Commun. 2016 Feb 17;4:14. doi: 10.1186/s40478-016-0277-8.
CSF complement 3 and factor H are staging biomarkers in Alzheimer's disease.
Hu WT, Watts KD, Tailor P, Nguyen TP, Howell JC, Lee RC, Seyfried NT, Gearing M, Hales CM, Levey AI, Lah JJ, Lee EK; Alzheimer’s Disease Neuro-Imaging Initiative. |
| Background Information | Neurodegenerative disease is a condition characterized by the deterioration of neurons or their myelin sheath over time in the brain and/or spinal cord. These neurons are responsible for such everyday activities as processing sensory information, making decisions, and controlling movement. Because these cells are not easily regenerated, excessive cumulative damage can lead to age-related diseases such as Alzheimer's and Parkinson's disease, as well as other conditions such as amyotrophic lateral sclerosis (ALS) and epilepsy. These disorders are devastating and expensive, both on a personal and global level, and as population demographics continue to change, a therapeutic solution is critical. Consequently, research is underway to identify biomarkers that will help scientists not only understand the pathogenesis of neurodegenerative disease, but also identify people with these disorders before the onset of symptoms and potentially provide new therapeutic tools. |
| Product Information
|
| Detection method | Luminex xMAP |
| Configuration | Design your multiplex kit by choosing available analytes within this panel. |
| Precision, % |
- Intra-assay:< 10
- Inter-assay:
α2-Macroglobulin & Complement C3 < 10
All other analytes < 20
|
| Panel Type | MAGNETIC Neuroscience |
| Quality Level | MQ200
|
| Applications
|
| Application | The analytes available for this multiplex kit are: α2-Macroglobulin, Apo Al, Apo CIII, Apo E, Complement C3 and Complement Factor H. |
| Key Applications |
|
| Application Notes | • This is a 2-hour incubation assay.
• This assay requires 25 μL of 1:40,000 diluted serum/plasma or 1:400 diluted CSF per well. |
| Biological Information
|
| Species Reactivity |
|
| Analytes Available |
- α2-Macroglobulin
- Apo Al
- Apo CIII
- Apo E
- Complement C3
- Complement Factor H
|
| Assay Panel | Everything you need in a single kit. |
| Cross Reactivity | Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible. |
| Accuracy |
- α2-Macroglobulin 104%
- Apo AI 102%
- Apo CIII 105%
- Apo E 110%
- Complement C3 75%
- Complement Factor H 105%
|
| Physicochemical Information
|
| Sensitivity |
- See protocol for sensitivities of individual analytes
|
| Standard Curve Range |
- Apo CIII: 0.01 – 40 ng/mL
- Apo E, Complement C3: 0.05 – 200 ng/mL
- Complement Factor H: 0.3 – 1,000 ng/mL
- α-2-Macroglobulin: 0.5 – 2,000 ng/mL
- Apo A1: 0.7 – 3,000 ng/mL
|
| Product Usage Statements
|
| Usage Statement |
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
|
| Storage and Shipping Information
|
| Storage Conditions | Recommended storage for kit components is 2 - 8°C. |
| Packaging Information
|
| Material Size | 96-well plate |
