重要规格表
| Empirical Formula | CAS # |
|---|---|
| C₂₀H₄₀N₄O₁₀ · 2H₂SO₄ | 108321-42-2 |
| Description | |
|---|---|
| Overview | Aminoglycoside related to gentamycin that inhibits prokaryotic and eukaryotic protein synthesis. Toxic to bacteria, yeast, protozoans, helminths, higher plant, and mammalian cells. Widely used in the selection of eukaryotic expression vectors carrying the bacterial neor/kanr genes. The product of these genes, aminoglycoside 3′-phosphotransferase, inactivates G418, neomycin, and kanamycin by phosphorylation. Introduction of either of these genes into cells can confer resistance to G418, which enables cells to grow in media containing G418. |
| Catalogue Number | 509290 |
| Brand Family | Calbiochem® |
| Synonyms | NMD Inhibitor I |
| References | |
|---|---|
| References | Ethier, S.P., and Taback, E. 1993. Cancer Lett. 74, 189. Santerre, R.F., et al. 1991. Methods Mol. Biol. 7, 245. Maniatis, T., et al. 1989. In Molecular Cloning, A Laboratory Manual, Second Edition, Cold Spring Harbor, NY. Edwards, S.A., and Adamson, E.D. 1987. J. Cell Physiol. 133, 46. Ernst, J.F., and Chan, R.K. 1985. J. Bacteriol. 163, 8. Canaani, D., and Berg, P. 1982. Proc. Natl. Acad. Sci. USA 79, 5166. Hirth, K.P., et al. 1982. Proc. Natl. Acad. Sci. USA 79, 7356. Ursic, D., et al. 1981. Biochem. Biophys. Res. Commun. 101, 1031. Jimenez, A., and Davies, J. 1980. Nature 287, 869. |
| Product Information | |
|---|---|
| CAS number | 108321-42-2 |
| Form | White powder |
| Hill Formula | C₂₀H₄₀N₄O₁₀ · 2H₂SO₄ |
| Chemical formula | C₂₀H₄₀N₄O₁₀ · 2H₂SO₄ |
| Quality Level | MQ200 |
| Biological Information | |
|---|---|
| Biological activity | Assay: ≥730 µg/mg |
| Purity | ≥90% by HPLC |
| Physicochemical Information | |
|---|---|
| Contaminants | Heavy metals: ≤100 ppm |
| Safety Information according to GHS | |
|---|---|
| RTECS | CB9378500 |
| Storage and Shipping Information | |
|---|---|
| Ship Code | Ambient Temperature Only |
| Toxicity | Standard Handling |
| Storage | +15°C to +30°C |
| Do not freeze | Ok to freeze |
| Special Instructions | Solubilization in H₂O at 100 mg/ml yields a clear, colorless solution. |
