millipore,
密理博,MSCRMAG-42K,MILLIPLEX MAP Mouse Soluble Cytokine Receptor Magnetic Bead Panel - Immunology Multiplex Assay
| Description
|
| Catalogue Number | MSCRMAG-42K |
| Trade Name |
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| Description | MILLIPLEX MAP Mouse Soluble Cytokine Receptor Magnetic Bead Panel - Immunology Multiplex Assay |
| Overview | The MILLIPLEX MAP Mouse Soluble Cytokine Receptor Panel contains 13 metastasis biomarkers that have also been identified in a variety of therapeutic areas. Coupled with the Luminex® xMAP® platform in magnetic bead format, this panel enables researchers to focus on discovery with the advantage of simultaneous quantitative multiplex detection leading to speed and sensitivity. |
| Background Information | Cytokine receptors constitute an integral part of the cytokine biology. Like cytokines, cytokine receptors are involved in normal physiological and pathological processes of almost all disease states. Soluble cytokine receptors naturally arise from genes encoding membrane-bound receptors or are direct derivatives of the receptors themselves. The discovery that soluble cytokine receptors are involved in regulating excessive inflammatory responses and modulating immune events has stimulated significant research interest in their potential role as immunotherapeutic agents. Many of these soluble cytokine receptors have the ability to inhibit the binding and biological activity of their cytokine ligands, making them very specific cytokine antagonists. |
| Product Information
|
| Detection method | Luminex xMAP |
| Configuration | Design your multiplex kit by choosing available analytes within this panel. |
| Precision, % |
- Intra-assay: < 7
- Inter-assay: < 12
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| Panel Type | MAGNETIC Cytokines/Chemokines |
| Quality Level | MQ200
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| Applications
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| Application | Simultaneously analyze multiple cytokine and chemokine biomarkers with Bead-Based Multiplex Assays using the Luminex technology, in mouse serum, plasma and cell culture samples. |
| Key Applications |
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| Application Notes | • An overnight incubation assay is recommended.
• This assay requires 25 μL of 1:5 diluted serum and plasma or tissue/cell culture supernatant |
| Biological Information
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| Species Reactivity |
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| Analytes Available |
- sCD30 (sTNFRSF8)
- sgp130
- sIL-1RI (sCD121a)
- sIL-1RII (sCD121b)
- sIL-2Rα (sCD25)
- sIL-4R (sCD124)
- sIL-6R (sCD126)
- sRAGE
- sTNFRI (sTNFRSF1A)
- sTNFRII (sTNFRSF1B)
- sVEGFR1 (sFlt-1)
- sVEGFR2 (sFlk-1)
- sVEGFR3 (sFlt-4)
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| Assay Panel | Everything you need in a single kit. |
| Accuracy |
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| Physicochemical Information
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| Sensitivity |
- Refer to kit protocol for sensitivities of individual biomarkers.
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| Linearity of Dilution | Contact Technical Service for this information |
| Standard Curve Range |
- sCD30, sgp130, sIL-6R, sRAGE, sVEGFR1, sVEGFR2, sVEGFR3: 24.4 – 100,000 pg/mL
- sIL-1RI, sIL-1RII, sIL-2Rα, sIL-4R, sTNFRII: 12.2 – 50,000 pg/mL
- sTNFRI: 4.9 – 20,000 pg/mL
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| Product Usage Statements
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| Usage Statement |
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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| Packaging Information
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| Material Size | 96-well plate |
