millipore,密理博,616394,TPEN - CAS 16858-02-9

millipore,密理博,616394,TPEN - CAS 16858-02-9 - Calbiochem

重要规格表

Empirical Formula	CAS #
C₂₆H₂₈N₆	16858-02-9

Description
Overview	Lipid-soluble heavy metal chelator that crosses artificial and natural membranes. Auxiliary reagent in certain techniques used for measuring free Ca²⁺ levels in cells. Also useful in extracting Aβ amyloid deposits from Alzheimer’s disease brain tissue. Has extremely high affinity for heavy metals but low affinity for Ca²⁺ and Mg²⁺. Induces DNA fragmentation when chelated with Zn²⁺ and induces apoptosis in thymocytes. Strips heavy metals from liposome-trapped QUIN 2 (Cat. No. 551826).
Catalogue Number	616394
Brand Family	Calbiochem®
Synonyms	N,N,Nʹ,Nʹ-tetrakis-(2-Pyridylmethyl)ethylenediamine

References
References	Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209. Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223. Aballay, A., et al. 1995. Biochem. J. 312, 919. Jiang, S., et al. 1995. Lab. Invest. 73, 111. Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539. McCabe, M.J., et al. 1993. Lab. Invest. 69, 101. Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553. Baba, A., et al. 1991. Brain Res. 557, 103. Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224. Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593. Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345. Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.

References

Fonte, J., et al. 2001. J. Alzheimer’s Dis. 3, 209.
Cherny, R.A., et al. 1999. J. Biol. Chem. 274, 23223.
Aballay, A., et al. 1995. Biochem. J. 312, 919.
Jiang, S., et al. 1995. Lab. Invest. 73, 111.
Sheridan, R.E. and Deshpande, S.S. 1995. Toxicon 33, 539.
McCabe, M.J., et al. 1993. Lab. Invest. 69, 101.
Hinkle, P.M., et al. 1992. J. Biol. Chem. 267, 25553.
Baba, A., et al. 1991. Brain Res. 557, 103.
Forbes, I.J., et al. 1991. Exp. Cell Res. 195, 224.
Csermely, P. and Somogyi, J. 1989. J. Cellular Physiol. 138, 593.
Raspe, E., et al. 1989. Eur. J. Pharmacol. 163, 345.
Arslan, L.P., et al. 1985. J. Biol. Chem. 260, 2719.

Product Information
CAS number	16858-02-9
Form	Tan solid
Hill Formula	C₂₆H₂₈N₆
Chemical formula	C₂₆H₂₈N₆
Structure formula Image
Quality Level	MQ100

Biological Information
Purity	≥97% by titration

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C) under an inert gas. Alternately, acidify (pH ≤3) with HCl for long term storage. Stock solutions are stable for up to 3 months at -20°C.