重要规格表
| Empirical Formula | CAS # |
|---|---|
| C₂₉H₃₉N₅O₈ | 220620-09-7 |
| Description | |
|---|---|
| Overview | A broad-spectrum glyclcycline class of antimicrobial agent that is active against both Gram positive and Gram negative bacteria. Exhibits toxicity for human AML cells at all stages of development in both in vitro and in vivo models. Selectively kills leukemic stem and progenitor cells (LD50 ~10 µM) and reduces the repopulating ability of the primary AML cells while sparing normal hematopoietic cells. Its action on growth and viability of eukaryotic cells is shown to be due to its inhibitory effects on mitochondrial protein translation and respiratory complex activity. |
| Catalogue Number | 610225 |
| Brand Family | Calbiochem® |
| Synonyms | 9-t-Butylglycylamido-minocycline |
| References | |
|---|---|
| References | Skrtic, M., et al. 2011. Cancer Cell 20, 674. Olson, M.W., et al. 2006. Antimicrob. Agents Chemother. 50, 2156. Stein, G.E., and Craig, W.A., 2006. Clin. Infect Dis. 43, 518. Livermore, D.M., 2005. J. Antimicrob. Chemother. 56, 611. |
| Product Information | |
|---|---|
| CAS number | 220620-09-7 |
| Form | Orange powder |
| Hill Formula | C₂₉H₃₉N₅O₈ |
| Chemical formula | C₂₉H₃₉N₅O₈ |
| Structure formula Image |  |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥99% by HPLC |
| Safety Information | |
|---|---|
| R Phrase | R: 36-60-61 Irritating to eyes. May impair fertility. May cause harm to the unborn child. |
| S Phrase | S: 26-36-45 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
| Storage and Shipping Information | |
|---|---|
| Ship Code | Ambient Temperature Only |
| Toxicity | Irritant |
| Storage | +2°C to +8°C |
| Protect from Light | Protect from light |
| Do not freeze | Ok to freeze |
| Special Instructions | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
