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密理博,616452,TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem
重要规格表
| Empirical Formula | CAS # |
|---|
| C₁₇H₁₃N₅
| 446859-33-2
|
| Description
|
| Overview | A cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC50 > 16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158). |
| Catalogue Number | 616452 |
| Brand Family |
Calbiochem®
|
| Synonyms | ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine |
| References
|
| References | Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
Ichida, J. K., et al. 2009. 5, 491. |
| Product Information
|
| CAS number | 446859-33-2 |
| ATP Competitive | Y |
| Form | Yellow solid |
| Hill Formula | C₁₇H₁₃N₅ |
| Chemical formula | C₁₇H₁₃N₅ |
| Structure formula Image |  |
| Quality Level | MQ100
|
| Biological Information
|
| Primary Target | ALKS binding |
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| Primary Target IC<sub>50</sub> | 23 nM |
| Secondary target | ALK 5 auto phosphorylation (IC₅₀ = 4 nM) |
| Purity | ≥95% by HPLC |
| Physicochemical Information
|
| Cell permeable | Y |
| Storage and Shipping Information
|
| Ship Code |
Ambient Temperature Only
|
| Toxicity |
Standard Handling
|
| Storage |
+2°C to +8°C
|
| Protect from Light |
Protect from light
|
| Do not freeze |
Ok to freeze
|
| Special Instructions | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Packaging Information
|
| Packaged under inert gas |
Packaged under inert gas
|
