重要规格表
| CAS # |
|---|
| 9041-93-4 |
| Description | |
|---|---|
| Overview | Mixture of cytotoxic glycopeptides that inhibits DNA synthesis by reacting with DNA and causing strand scission. Acts by generating hydroxyl free radicals which cleave N-glycosidic bonds and cause base elimination (mainly T) and phosphodiester bond scission. An anti-neoplastic agent. Bleomycin has been used in the treatment of squamous cell carcinomas, testicular tumors, and malignant lymphomas. |
| Catalogue Number | 203401 |
| Brand Family | Calbiochem® |
| References | |
|---|---|
| References | Tounekki, O., et al. 1994. Bull. Cancer 81, 1043. Chauvergne, J., et al. 1993. Bull. Cancer 80, 70. Ikeda, S., et al. 1991. Anal. Biochem. 192, 96. Hait, W.N., et al. 1990. Cancer Res. 50, 6636. Arkin, H., et al. 1989. Cancer Res. 49, 6556. Wu, J.C., et al. 1983. J. Biol. Chem. 258, 4694. Takita, T., et al. 1968. Antibiotics 21, 79. |
| Product Information | |
|---|---|
| CAS number | 9041-93-4 |
| Form | White to off-white solid |
| Hygroscopic | Hygroscopic |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Biological activity | Potency: 1.5-2.0 U/mg |
| Purity | ≥90% by HPLC (A₂ + B₂) |
| Safety Information according to GHS | |
|---|---|
| RTECS | EC5991990 |
| Safety Information | |
|---|---|
| R Phrase | R: 20/21/22-36/37/38-40-42/43 Harmful by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Limited evidence of a carcinogenic effect. May cause sensitization by inhalation and skin contact. |
| S Phrase | S: 22-26-36/37/39-45 Do not breathe dust. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). |
| Storage and Shipping Information | |
|---|---|
| Ship Code | Ambient Temperature Only |
| Toxicity | Harmful & Carcinogenic / Teratogenic |
| Storage | +2°C to +8°C |
| Hygroscopic | Hygroscopic |
| Do not freeze | Ok to freeze |
| Special Instructions | Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. Aqueous stock solutions (≥3 units/ml) are stable for up to 1 month at 4°C or for up to 3 months at -20°C. |
