| Overview | Carbenicillin is an antibiotic that interferes with the terminal reaction in bacterial wall synthesis. It is recommended for use in place of ampicillin to maintain the selective marker bla (β-lactamase or ampicillin resistance). Ampicillin selection tends to be lost in cultures as the drug is degraded by the secreted β-lactamase enzyme and by the drop in pH that usually accompanies bacterial fermentation. A way to avoid this loss of drug resistance is to use the related drug, carbenicillin, which is less sensitive to low pH. |
