millipore,
密理博,220320,Chetomin, Chaetomium sp. - CAS 1403-36-7 - Calbiochem
重要规格表
| Empirical Formula | CAS # |
|---|
| C₃₁H₃₀N₆O₆S₄
| 1403-36-7
|
| Description
|
| Overview | A cell-permeable dithiodiketopiperazine antimicrobial agent that disrupts the CH1 domain structure of p300, an important mediator of tumor hypoxia adaptation, and prevents the association of p300 with CH1-interacting proteins, such as HIF-1α and STAT2. Shown to attenuate hypoxia-induced transcription in vitro (IC50 = 20 nM and < 10 nM in inhibiting secreted and cellular VEGF, respectively, in Hep38 cells) and inhibit tumor growth by inducing necrosis in vivo (1 mg/kg, i.v., daily in tumor xenografted NCr/Nude mice). Does not affect the transcriptional activity of PAR, SREBP2, or SRC-1, whose association with p300 is not mediated via CH1 domain. |
| Catalogue Number | 220320 |
| Brand Family |
Calbiochem®
|
| Synonyms | CS-1, CTM |
| References
|
| References | Fujimoto, H., et al. 2004. J. Nat. Prod. 67, 98.
Kung, A.L., et al. 2004. Cancer Cell 6, 33. |
| Product Information
|
| CAS number | 1403-36-7 |
| Form | Off-white solid |
| Hill Formula | C₃₁H₃₀N₆O₆S₄ |
| Chemical formula | C₃₁H₃₀N₆O₆S₄ |
| Structure formula Image |  |
| Quality Level | MQ100
|
| Biological Information
|
| Purity | ≥97% by HPLC |
| Safety Information according to GHS
|
| RTECS | FM3038000 |
| Storage and Shipping Information
|
| Ship Code |
Shipped with Blue Ice or with Dry Ice
|
| Toxicity |
Toxic
|
| Hazardous Materials Attention: |
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges.
|
| Storage |
-20°C
|
| Protect from Light |
Protect from light
|
| Do not freeze |
Ok to freeze
|
| Special Instructions | Following reconstitution in fresh, anhydrous DMSO, aliquot and freeze (-20°C). Stock solutions for up to 3 months at -20°C. |
| Packaging Information
|
| Packaged under inert gas |
Packaged under inert gas
|
