millipore,
密理博,RV3MAG-26K,MILLIPLEX MAP Rat Vascular Injury Magnetic Bead Panel 3 - Toxicity Multiplex Assay
重要规格表
| Analytes Available | Species Reactivity | Key Applications | Multiplexing Ordering Requirements | Detection Methods |
|---|
| α-1-Acid Glycoprotein (AGP), α-2-Macroglobulin (A2M), Fibrinogen, Haptoglobin
| R
| Mplex
| Please note: Sample Type must be selected when configuring this kit. Fibrinogen cannot be measured in serum samples.
| Luminex xMAP
|
| Description
|
| Catalogue Number | RV3MAG-26K |
| Trade Name |
|
| Description | MILLIPLEX MAP Rat Vascular Injury Magnetic Bead Panel 3 - Toxicity Multiplex Assay |
| Overview | The MILLIPLEX® MAP Rat Vascular Injury Magnetic Bead Panel 3 contains all the components necessary to measure the following four biomarkers in any combination using Luminex® xMAP® technology: α-1-Acid Glycoprotein (AGP), α-2-Macroglobulin (A2M), Fibrinogen (NOTE: Fibrinogen cannot be measured in serum samples), Haptoglobin. The kit uses a 96-well format, contains a lyophilized standard cocktail, two quality controls and can measure up to 38 serum or plasma samples in duplicate. |
| Background Information | Vascular injury is important to address during the preclinical safety study of drugs. A lack of well-defined mechanisms of drug-induced vascular injury (DIVI) in animals, and the absence of specific, qualified biomarkers have become significant barriers in the development of new therapeutic treatments. In the past, hemodynamics, such as heart rate and mean arterial blood pressure, were used to measure DIVI risks but these only targeted single biomarkers. Today, some of the known vascular injury mechanisms are related to vascular wall shear and/or circumferential “hoop” stress, drug/chemical toxicity, and immunological mediation. With these known biomechanics, primary targets (smooth muscle, endothelial and immune-mediated cells) yield a number of promising candidate biomarkers for DIVI study. We provide valuable research assays to investigate multiple biomarkers of vascular injury in rat serum and plasma samples using the Luminex xMAP® instrument platform. |
| Product Information
|
| Detection method | Luminex xMAP |
| Configuration | Design your multiplex kit by choosing available analytes within this panel. |
| Precision, % |
- Inter-assay: < 15
- Intra-Assay: < 10
|
| Multiplex Ordering Requirements | Please note: Sample Type must be selected when configuring this kit. Fibrinogen cannot be measured in serum samples. |
| Panel Type | MAGNETIC Toxicity |
| Quality Level | MQ200
|
| Applications
|
| Application | The analytes available for this multiplex kit are: α-1-Acid Glycoprotein (AGP), α-2-Macroglobulin (A2M), Fibrinogen, Haptoglobin.
NOTE: Fibrinogen cannot be measured in serum samples |
| Key Applications |
|
| Application Notes | • This is an overnight assay.
• This assay requires 25 µL of 1:40,000 diluted serum or plasma sample per well in kit Assay Buffer (please dilute per protocol instructions). |
| Biological Information
|
| Specificity | There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel. |
| Species Reactivity |
|
| Analytes Available |
- α-1-Acid Glycoprotein (AGP)
- α-2-Macroglobulin (A2M)
- Fibrinogen
- Haptoglobin
|
| Assay Panel | Everything you need in a single kit. |
| Cross Reactivity | There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes within a panel. |
| Accuracy |
|
| Physicochemical Information
|
| Sensitivity |
- See kit protocol for individual analytes sensitivities.
|
| Linearity of Dilution | Contact technical support for this information. |
| Standard Curve Range |
- α-1-Acid Glycoprotein (AGP): 0.4 – 300 ng/mL
- α-2-Macroglobulin (A2M): 0.1 – 100 ng/mL
- Fibrinogen: 0.3 – 250 ng/mL
- Haptoglobin: 0.3 – 200 ng/mL
|
| Product Usage Statements
|
| Usage Statement |
- Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
|
| Storage and Shipping Information
|
| Storage Conditions | Recommended storage for kit components is 2 - 8°C. |
| Packaging Information
|
| Material Size | 96-well plate |
