重要规格表
| Empirical Formula | CAS # |
|---|
| C₁₉H₁₀N₂O₃ • CH₃CO₂H
| 52029-86-4
|
| Description
|
| Overview | A cell-permeable and reversible naphthoyl fused benzimidazole compound that acts as a highly selective, potent, ATP-competitive inhibitor of Ca2+/calmodulin-dependent protein kinase kinase (CaM-KK) [IC50 = 120 ng/ml and 40 ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively]. Binds to the catalytic domain of CaM-KK, and inhibits autophosphorylation. Does not significantly affect the activities of CaM-KII, MLCK (IC50 = ~10 µg/ml), CaM-KI, CaM-KIV, PKA, PKC, and p42 MAP kinase (IC50 >10 µg/ml). Has also been reported to inhibit phosphorylation of AMP-activated protein kinase (AMPK). |
| Catalogue Number | 570250 |
| Brand Family |
Calbiochem®
|
| Synonyms | 7H-Benz[de]benzimidazo[2,1-a]isoquinoline-7-one-3-carboxylic Acid, Acetate, 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid, Acetate |
| References
|
| References | Levine, Y., et al. 2007. J. Biol. Chem. 282, 20351.
Tokumitsu, H., et al. 2003. J. Biol. Chem. 278, 10908.
Tokumitsu, H., et al. 2002. J. Biol. Chem. 277, 15813. |
| Product Information
|
| CAS number | 52029-86-4 |
| ATP Competitive | Y |
| Form | Yellow solid |
| Hill Formula | C₁₉H₁₀N₂O₃ • CH₃CO₂H |
| Chemical formula | C₁₉H₁₀N₂O₃ • CH₃CO₂H |
| Hygroscopic |
Hygroscopic
|
| Reversible | Y |
| Structure formula Image |  |
| Quality Level | MQ100
|
| Biological Information
|
| Primary Target | CaM-KKα |
50$anchor_PDP_OverviewTab_Product_Biological_Info_Primary Target IC50" value="Biological Information">
| Primary Target IC<sub>50</sub> | 120 ng/ml and 40 ng/ml for CaM-KKα and CaM-KKβ isoforms, respectively |
| Purity | ≥95% by HPLC |
| Physicochemical Information
|
| Cell permeable | Y |
| Storage and Shipping Information
|
| Ship Code |
Ambient Temperature Only
|
| Toxicity |
Standard Handling
|
| Storage |
+2°C to +8°C
|
| Protect from Light |
Protect from light
|
| Hygroscopic |
Hygroscopic
|
| Do not freeze |
Ok to freeze
|
| Special Instructions | Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Packaging Information
|
| Packaged under inert gas |
Packaged under inert gas
|
