重要规格表
| Empirical Formula | CAS # |
|---|---|
| C₁₄H₁₄N₄O₃ | 737-86-0 |
| Description | |
|---|---|
| Overview | A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe3+ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity. |
| Catalogue Number | 528110 |
| Brand Family | Calbiochem® |
| Synonyms | pyridoxal isonicotinoyl hydrazone, Iron Chelator III |
| References | |
|---|---|
| References | Buss, J.L., et al. 2002. Biochem. Pharmacol. 64, 1689. Thomas, S.R., et al. 2001. J. Immunol. 166, 6332. Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta 1523, 154. Blaha, K., et al. 1998. Blood 11, 4368. Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med. 131, 306. Richardson, D.R.,et al. 1995. Blood 86, 4295. Richardson, D.R., et al. 1994. J. Lab. Clin. Med. 124, 660. Ponka, P., et al. 1988. Biochim. Biophys. Acta 967, 122. Ponka, P., et al. 1984. Biochim. Biophys. Acta 802, 477. Ponka, P., et al. 1979. FEBS Lett. 97, 317. |
| Product Information | |
|---|---|
| CAS number | 737-86-0 |
| Form | Yellow solid |
| Hill Formula | C₁₄H₁₄N₄O₃ |
| Chemical formula | C₁₄H₁₄N₄O₃ |
| Structure formula Image |  |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥99% by HPLC |
| Storage and Shipping Information | |
|---|---|
| Ship Code | Ambient Temperature Only |
| Toxicity | Standard Handling |
| Storage | +2°C to +8°C |
| Protect from Light | Protect from light |
| Do not freeze | Ok to freeze |
| Special Instructions | Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C. |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
