millipore,
密理博,268320,Daptomycin, Streptomyces sp. - CAS 103060-53-3 - Calbiochem
重要规格表
| Empirical Formula | CAS # |
|---|
| C₇₂H₁₀₁N₁₇O₂₆
| 103060-53-3
|
| Description
|
| Overview | A semi-synthetic cyclic polypeptide antibiotic that is active against vancomycin-resistant gram-positive bacteria, including enterococci and Staphylococcus aureus (MIC50 = 0.13 µg/ml). Its bactericidal activities have been attributed to its role in disruption of membrane potential and increased efflux of potassium ions from bacterial cells, which lead to disruption of protein, DNA, and RNA synthesis. Exhibits superior bactericidal properties compared to vancomycin (Cat. No. 627850) even in the presence of serum. |
| Catalogue Number | 268320 |
| Brand Family |
Calbiochem®
|
| Synonyms | Cubicin, Dapcin |
| References
|
| References | Kosmidis, C. and Levine, D.P., 2010. Expert Opin. Pharmacother. 11, 615.
Cui, L., et al. 2006. Antimicrob. Agents Chemother. 50, 1079.
Silverman, J.A., et al. 2003. Antimicrob. Agents Chemother. 47, 2538.
Rybak, M.J., et al. 2000. Antimicrob. Agents Chemother. 44, 1062. |
| Product Information
|
| CAS number | 103060-53-3 |
| Form | Off-white to pale yellow solid |
| Hill Formula | C₇₂H₁₀₁N₁₇O₂₆ |
| Chemical formula | C₇₂H₁₀₁N₁₇O₂₆ |
| Quality Level | MQ100
|
| Biological Information
|
| Purity | ≥98% by HPLC |
| Storage and Shipping Information
|
| Ship Code |
Ambient Temperature Only
|
| Toxicity |
Standard Handling
|
| Storage |
+2°C to +8°C
|
| Protect from Light |
Protect from light
|
| Do not freeze |
Ok to freeze
|
| Special Instructions | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Packaging Information
|
| Packaged under inert gas |
Packaged under inert gas
|
